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马占芳

        称:教授/博士生导师

        别:男

出生年月:19659

        业:物理化学

办公电话:010-68907046

Emailmazhanfang@126.com

【个人情况综述】

马占芳,教授(博导)、系主任

长期从事胶体与界面化学领域的研究工作,在纳米材料的制备和组装、新型纳米生物探针研制、纳米生物识别与检测、电化学生物传感器等方面做了系统的研究工作。在包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Funct. Mater., Small, Chem. Mater., Biosens. Bioelectron.等在内的国际主流学术期刊上发表研究论文130余篇,这些文章被SCI论文正面引用2600余次。2005年获得国家自然科学奖二等奖(第四位)。癌症早期诊断纳米新技术北京市知识创新团队负责人。

【学习工作简历】

2006.10 - 现在        首都师范大学化学系,教授,博导;

2003.09 - 2006.09     东北师范大学化学学院化学系,教授(博导)

2002.11 - 2003.08      日本东京大学化学系,日本学术振兴会(JSPS)外国人特别研究员

2000.09 - 2002.07     清华大学生物科学与技术系,博士后

1997.09 - 2000.07     中科院感光化学研究所,博士研究生

1990.08 - 1997.08      东北师范大学化学系,助教、讲师

1983.09 - 1990.07      东北师范大学化学系,本科生、硕士研究生

【主要科研方向】

1、纳米材料的功能化制备与组装

2、纳米生物识别与检测

3、电化学生物传感器

 

【主要科研项目】

1国家自然科学基金面上项目:2017-2020

基于导电水凝胶构筑超灵敏、稳定的非标记电流型肿瘤标志物传感界面的新方法研究” (21673143)。

2、北京市自然科学基金面上项目:2017-2019

“新型导电水凝胶的制备及其在电化学免疫检测肿瘤标志物中的应用”2172016

3国家自然科学基金项目:2013-2016

多靶标肿瘤标志物电化学免疫传感界面构建新方法研究21273153)。

 4北京市自然科学基金项目:2013-2015

铸膜法构建高重现性的癌胚抗原电化学免疫传感器2132008

5、北京市属市管高校人才强教计划知识创新团队:2010-2012

 “癌症早期诊断纳米新技术PHR20100718)。

6、北京市教委社会发展计划项目:2008-2010

 “寡核苷酸与金纳米棒复合的新型DNA探针的研制KM200810028010)。

7、国家自然科学基金项目:2005

聚合丁二炔敏感膜生物分子识别变色机理研究” (20443011)

8、吉林省科技发展计划项目:2005-2007

      “一种比色检测DNA分子的变色薄膜和溶液的制备” (20050558)

【代表性科研成果(论文、专利)】

1. J. C. Zhao, Z. F. Ma*. Ultrasensitive detection of prostate specific antigen by electrochemical aptasensor using enzyme-free recycling amplification via target-induced catalytic hairpin assembly. Biosens. Bioelectron. 2018, 102, 316-320.

2. L. H. Zhao, H. L. Han, Z. F. Ma*. Improved screen-printed carbon electrode for multiplexed label-free amperometric immuniosensor: Addressing its conductivity and reproducibility challenges. Biosens. Bioelectron. 2018, 101, 304-310.

3. Z. X. Tang, Y. Y. Fu, Z. F. Ma*. Bovine serum albumin as an effective sensitivity enhancer for peptide-based amperometric biosensor for ultrasensitive detection of prostate specific antigen. Biosens. Bioelectron. 2017, 94, 394-399.

4. Z. X. Tang, L. Y. Wang, Z. F. Ma*. Triple sensitivity amplification for ultrasensitive electrochemical detection of prostate specific antigen. Biosens. Bioelectron.2017, 92, 577-582.

5. Z. X. Tang, Y. Y. Fu, Z. F. Ma*. Multiple signal amplification strategy for ultrasensitive label-free electrochemical immunoassay for carbohydrate antigen 24-2 based on redox hydrogel. Biosens. Bioelectron. 2017, 91, 299-305.

6. J. Shan, Z. F. Ma*. A review on amperometric immunoassays for tumor markers based on the use of hybrid materials consisting of conducting polymers and noble metal nanomaterial. Microchim. Acta 2017, 184, 969-979.

7. Z. X. Tang, Z. F. Ma.* Ratiometric ultrasensitive electrochemical immunosensor based on redox substrate and immunoprobe. Sci. Rep. 2016, 6, 35440.

8. L. Y. Wang, Q. F. Rong, Z. F. Ma*. Construction of electrochemical interface for multiple cancer biomarkers detection. Electroanalysis 2016, 28, 1692-1699. (Invited Review)

9. H. Q. Wang, Q. F. Rong, Z. F. Ma*. Polyhydroquinone-graphene composite as new redox species for ultrasensitive electrochemical detection of cytokeratins antigen 21-1. Sci. Rep. 2016, 6, 30623.

10. L. Y. Wang, J. Shan, F. Feng, Z. F. Ma*. Novel redox species polyaniline derivative-Au/Pt as sensing platform for label-free electrochemical immunoassay of carbohydrate antigen 199. Anal. Chim. Acta 2016, 911, 108-113.

11. Q. F. Rong, F. Feng, Z. F. Ma*. Metal ions doped chitosan-poly(acrylic acid) nanospheres: synthesis and their application in simultaneously electrochemical detection of four markers of pancreatic cancer. Biosens. Bioelectron. 2016, 75, 148-154.

12. L. Y. Wang, F. Feng, Z. F. Ma*. Novel electrochemical redox-active species: one-step synthesis of polyaniline derivative-Au/Pd and its application for multiplexed immunoassay. Sci. Rep. 2015, 5, 16855.

13. Z. F. Ma*, N. Liu. Design of immunoprobes for electrochemical multiplexed tumor marker detection. Expert Review of Molecular Diagnostics 2015, 15, 1075-1083. (Invited Review)

14. Q. F. Rong, H. L. Han, F. Feng, Z. F. Ma*. Network nanostructured polypyrrole hydrogel/Au composites as enhanced electrochemical biosensing platform. Sci. Rep. 2015, 5, 11440.

15. L. Y. Wang, N. Liu, Z. F. Ma*. Novel gold-decorated polyaniline derivatives as redox-active species for simultaneous detection of three biomarkers of lung cancer. J. Mater. Chem. B 2015, 3, 2867-2872.

16. T. Xu, N. Liu, F. Feng, Z. F. Ma*. Triple tumor markers assay based on carbon-gold nanocomposite. Biosens. Bioelectron. 2015, 70, 161-166.

17. Z. F. Wang, N. Liu, F. Feng, Z. F. Ma*. Synthesis of cadmium, lead and copper alginate nanobeads as immunosensing probes for the detection of AFP, CEA and PSA. Biosens. Bioelectron. 2015, 70, 98-105.

18. Z. M. Liu, Q. F. Rong, Z. F. Ma*, H. L. Han*. One-step synthesis of redox-active polymer/Au nanocomposites for electrochemical immunoassay of multiplexed tumor markers. Biosens. Bioelectron. 2015, 65, 307-313.

19. Z. F. Wang, X. Chen, Z. F. Ma*. Chitosan coated cupper and cadmium hexacyanocobaltate nanocubics as immunosensing probes for the construction of multiple analytes platform. Biosens. Bioelectron. 2014, 61, 562-568.

20. N. Liu, Z. M. Liu, H. L. Han, Z. F. Ma*. Graphene oxide reduced directly by redox probes for multiplexed detection of tumor markers. J. Mater. Chem. B 2014, 2, 3292 -3298.

21. N. Liu, Z. F. Wang, Z. F. Ma*. Platinum porous nanoparticles for the detection of cancer biomarkers: what are the advantages over existing techniques? Bioanalysis 2014, 6, 903-905. (Invited by editor)

22. T. Xu, X. L. Jia, X. Chen, Z. F. Ma*, Simultaneous electrochemical detection of multiple tumor markers using metal ions tagged immunocolloidal gold. Biosens. Bioelectron. 2014, 56, 174-179.

23. X. Chen, Z. F. Ma*. Multiplexed electrochemical immunoassay of biomarkers using chitosan nanocomposites. Biosens. Bioelectron. 2014, 55, 343-349.

24. Z. F. Wang, N. Liu, Z. F. Ma*. Platinum porous nanoparticles hybrid with metal ions as probes for simultaneous detection of multiplex cancer biomarkers. Biosens. Bioelectron. 2014, 53, 324-329.

25. X. L. Jia, Z. M. Liu, N. Liu, Z. F. Ma*. A label-free immunosensor based on graphene nanocomposites for simultaneous multiplexed electrochemical determination of tumor markers. Biosens. Bioelectron. 2014, 53, 160-166.

26. X. L. Jia, X. Chen, J. M. Han, J. Ma, Z. F. Ma*. Triple signal amplification using gold nanoparticles, bienzyme and platinum nanoparticles functionalized graphene as enhancers for simultaneous multiple electrochemical immunoassay. Biosens. Bioelectron. 2014, 53, 65-70.

27. N. Liu, Z. F. Ma*. Au-ionic liquid functionalized reduced graphene oxide immunosensing platform for simultaneous electrochemical detection of multiple analytes. Biosens. Bioelectron. 2014, 51, 184-190.

28. P. P. Bian, J. Zhou, Y. Y. Liu, Z. F. Ma*. One-step fabrication of intense red fluorescent gold nanoclusters and their application in cancer cell imaging. Nanoscale 2013, 5, 6161-6166.

29. X. Chen, X. L. Jia, J. Ma, Z. F. Ma*. Electrochemical immunosensor for simultaneous detection of multiplex cancer biomarkers based on graphene nanocomposites. Biosens. Bioelectron. 2013, 50, 356-361.

30. Y. X. Li, J. Ma, Z. F Ma*. Synthesis of gold nanostars with tunable morphology and theirelectrochemical application for hydrogen peroxide sensing. Electrochim. Acta 2013, 108, 435-440.

31. Q. Gao, J. M. Han, Z. F. Ma*. Polyamidoamine dendrimers-capped carbon dots/Au nanocrystal nanocomposites and its application for electrochemical immunosensor. Biosens. Bioelectron. 2013, 49, 323-328.

32. J. M. Han, J. Ma, Z. F. Ma*. One-step synthesis of poly(thionine)-Au nano-network and nanowires and its application for non-enzyme biosensing of hydrogen peroxide. Electrochem. Commun. 2013, 33, 47-50.

33. N. Liu, X. Chen, Z. F. Ma*. Ionic liquid functionalized graphene/Au nanocomposites and its application for electrochemical immunosensor. Biosens. Bioelectron. 2013, 48, 33-38.

34. J. M. Han, J. Ma, Z. F. Ma*. One-step synthesis of graphene oxide–thionine–Au nanocomposites and its application for electrochemical immunosensing. Biosens. Bioelectron. 2013, 47, 243-247.

35. Y. X. Li, Z. F. Ma*, Facile fabrication of truncated octahedral Au nanoparticles and its application for ultrasensitive surface enhanced Raman scattering immunosensing. Nanotechnology 2013, 24, 275605.

36. Z. M. Liu, Z. F. Ma*. Fabrication of an ultrasensitive electrochemical immunosensor for CEA by conducting long-chain polythiols. Biosens. Bioelectron. 2013, 46, 1-7.

37. X. B. Sun, Z. F. Ma*. Highly stable electrochemical immunosensor for carcinoembryonic antigen. Biosens. Bioelectron. 2012, 35, 470-474.

38. R. M. Wang, J. Di, J. Ma, Z. F. Ma*. Highly sensitive detection of cancer cells by electrochemical impedancespectroscopy. Electrochim. Acta 2012, 61, 179-184.

39. B. Liu, Z. F. Ma*, Synthesis of Ag2S-Ag nanoprisms and their use as oligonucleotide probes. Small 2011, 7, 1587-1592.

40. W. T. Shi, Z. F. Ma*, A novel label-free amperometric immunosensor for carcinoembryonic antigen based on redox membrane. Biosens. Bioelectron. 2011, 26, 3068-3071.

 41. W. T. Shi, Z. F. Ma*. Amperometric glucose biosensor based on a triangular silver nanoprisms/chitosan composite film as immobilization matrix. Biosens. Bioelectron. 2010, 26, 1098-1103.

42. Z. F. Ma*, L. Tian, T. T. Wang, C. G. Wang. Optical DNA detection based on gold nanorods aggregation. Anal. Chim. Acta 2010, 673, 179-184.

43. C. G. Wang, Y. Chen, T. T. Wang, Z. F. Ma*, Z. M. Su. Monodispersed gold nanorods embedded silica particles as novel Raman labels for biosensing. Adv. Funct. Mater. 2008, 18, 355-361.

44. C. G. Wang, Y. Chen, T. T. Wang, Z. F. Ma*, Z. M. Su, Biorecognition-driven self-assembly of gold nanorods: A rapid and sensitive approach toward antibody sensing. Chem. Mater. 2007, 19, 5809-5811.

45. C. G. Wang, Z. F. Ma*, T. T. Wang, Z. M. Su. Synthesis, assembly and biofunctionalization of silica-coated gold nanorods for colorimetric biosensing. Adv. Funct. Mater. 2006, 16, 1673-1678.

46. Z. F. Ma, S.-F. Sui. Naked-eye sensitive detection of Immunoglubulin G by enlargement of Au-nanoparticles immobilized in vitro. Angew. Chem. Int. Ed. 2002, 14, 2176-2179.

47. Z. F. Ma, J. R. Li, M. H. Liu, J. Cao, Z. Y. Zou, J. Tu, L. Jiang. Colorimetric detection of Escherichia coli by polydiacetylene vesicles functionalized with glycolipid. J. Am. Chem. Soc. 1998, 120, 12678-12679.

 

获奖情况

12009年获得北京市教育教学成果(高等教育)二等奖(第五位)

22005年获得国家自然科学奖二等奖(第四位)

31997年获得国家教委科技进步三等奖(第五位)

 

指导的研究生获国家奖学金情况

2017年 王辉强

2016年 单姣

2015年 荣勤峰、邢立文

2014年 徐腾、王子凤

2013年 贾新乐、卞平平、刘娜

2012年 孙晓斌(第一届国奖)