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马占芳

     称:教授/博士生导师

     别:男

     业:物理化学

办公电话:010-68907046

Emailmazhanfang@126.com

 

【个人情况综述】

 

马占芳,教授(博导)

长期从事胶体与界面化学领域的研究工作,在纳米材料的制备和组装、新型纳米生物探针研制、纳米生物识别与检测、电化学生物传感器等方面做了系统的研究工作。在包括Nature Communications, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Funct. Mater., Chem. Mater., Biosens. Bioelectron.等在内的国际主流学术期刊上发表研究论文150余篇,这些文章被SCI论文正面引用4600余次。入选爱思唯尔(Elsevier)发布的2019年中国高被引学者榜单。2005年获得国家自然科学奖二等奖(第四位)。癌症早期诊断纳米新技术北京市知识创新团队负责人。

 

【学习与工作简历】

 

2006.10 -现在      首都师范大学化学系,教授(博导)

2009.07 - 2020.06   首都师范大学化学系,系主任

2003.09 - 2006.09   东北师范大学化学学院化学系,教授(博导)

2002.11 - 2003.08   日本东京大学化学系,日本学术振兴会(JSPS)外国人特别研究员

2000.09 - 2002.07     清华大学生物科学与技术系,博士后

1997.09 - 2000.07     中科院感光化学研究所,博士生

1990.09 - 1997.08      东北师范大学化学系,任教

1983.09 - 1990.07     东北师范大学化学系,本科、硕士生

 

【主要科研方向】

 

1. 纳米材料的功能化制备与组装:设计并制备复合纳米材料,用于环境污染物的催化降解及处理。

2. 纳米生物识别与检测:设计并制备复合纳米材料,开发生物和化学分子、金属离子等的快速识别与检测方法。

3. 电化学生物传感器:设计并制备微纳米复合生物探针及电化学传感界面,用于重大疾病(如肿瘤)标志物的识别与检测。

 

【主要科研项目】

 

1. 国家自然科学基金面上项目:基于导电水凝胶构筑超灵敏、稳定的非标记电流型肿瘤标志物传感界面的新方法研究(21673143)2017-2020年;

2.北京市自然科学基金面上项目:新型导电水凝胶的制备及其在电化学免疫检测肿瘤标志物中的应用(2172016)2017-2019年;

3. 国家自然科学基金项目:多靶标肿瘤标志物电化学免疫传感界面构建新方法研究(21273153)2013-2016年;

4. 北京市自然科学基金面上项目:铸膜法构建高重现性的癌胚抗原电化学免疫传感器(2132008)2013-2015年;

5. 北京市属市管高校人才强教计划知识创新团队:癌症早期诊断纳米新技术(PHR20100718)2010-2012年;

6. 北京市教委社会发展计划项目:寡核苷酸与金纳米棒复合的新型DNA探针的研制(KM200810028010)2008-2010年;

7. 国家自然科学基金主任基金:聚合丁二炔敏感膜生物分子识别变色机理研究(20443011)2005年。

8. 吉林省科技发展计划项目:一种比色检测DNA分子的变色薄膜和溶液的制备(20050558)2005-2007年。

 

【代表性科研成果(论文、专利)】 

 

1. J. J. Feng. C. S. Chu, Z. F. Ma*. Fenton and Fenton-like catalysts for electrochemical immunoassay: A mini review. Electrochem. Commun. 2021, 106970. (Invited Review)

2. C. Zhang, N. N. Zhang, Y. Xu, J. J. Feng, T. Yao, F. Wang, Z. F. Ma*, H. L. Han*. Fenton reaction-mediated dual-attenuation of signal for ultrasensitive amperometric immunoassay. Biosens. Bioelectron. 2021, 178, 113009.

3. J. J. Feng, X. Y. Liang, Z. F. Ma*. New immunoprobe: dual-labeling ZIF-8 embellished with multifunctional bovine serum albumin lamella for electrochemical immunoassay of tumor marker. Biosens. Bioelectron. 2021, 175, 112853.

4. H. Q. Wang, Z. F. Ma*. Copper peroxide@ZIF-8 self-producing H2O2 triggered cascade reaction for amperometric immunoassay of carbohydrate antigen 19-9. Biosens. Bioelectron. 2020, 169, 112644.

5. Z. Wei, Y. X. Liu, Z. F. Ma*, H. L. Han*. Photo-induced microscale hyperthermia elevates catalytical timeliness on electrochemical immunosensor in situ. Biosens. Bioelectron. 2020, 150, 111951.

6. Y. X. Liu, Z. Wei, J. Zhou*, Z. F. Ma*. Simultaneous multi-signal quantification of a single bio-indicator improves the precision of serodiagnosis. Nature Communications 2019, 10, 5361.

7. C. Zhang, Z. F. Ma*. PtCu nanoprobe-initiated cascade reaction modulated iodide-responsive sensing interface for improved electrochemical immunosensor of neuron-specific enolase. Biosens. Bioelectron. 2019, 143, 111612.

8. S. Yin, Z. F. Ma*. Self-sacrificial label assisted electroactivity conversion of sensing interface for ultrasensitive electrochemical immunosensor. Biosens. Bioelectron. 2019, 140, 111355.

9. C. S. Chu, S. Rao, Z. F. Ma*, H. L. Han*. Copper and cobalt nanoparticles doped nitrogen-containing carbon frameworks derived from CuO-encapsulated ZIF-67 as high-efficiency catalyst for hydrogenation of 4-nitrophenol. Applied Catalysis B 2019, 256, 117792.

10. L. H. Zhao, S. Yin, Z. F. Ma*. Ca2+-triggered pH-response sodium alginate hydrogel precipitation for amplified sandwich-type impedimetric im-munosensor of tumor marker. ACS Sensors 2019, 4, 450-455.

11. Y. Zheng, Z. F. Ma*. Multifunctionalized ZIFs nanoprobe-initiated tandem reaction for signal amplified electrochemical immunoassay of carbohydrate antigen 24-2. Biosens. Bioelectron. 2019, 129, 42-49.

12. J. C. Zhao, D. Shu, Z. F. Ma*. Target-inspired Zn2+-dependent DNAzyme for ultrasensitive impedimetric aptasensor based on polyacrylic acid nanogel as amplifier. Biosens. Bioelectron. 2019, 127, 161-166.

13. Y. Zheng, L. H. Zhao, Z. F. Ma*. pH responsive label-assisted click chemistry triggered sensitivity amplification for ultrasensitive electrochemical detection of carbohydrate antigen 24-2. Biosens. Bioelectron. 2018, 115, 30-36.

14. J. C. Zhao, Z. F. Ma*. Ultrasensitive detection of prostate specific antigen by electrochemical aptasensor using enzyme-free recycling amplification via target-induced catalytic hairpin assembly. Biosens. Bioelectron. 2018, 102, 316-320.

15. L. H. Zhao, H. L. Han, Z. F. Ma*. Improved screen-printed carbon electrode for multiplexed label-free amperometric immuniosensor: Addressing its conductivity and reproducibility challenges. Biosens. Bioelectron. 2018, 101, 304-310.

16. Y. Zheng, Z. F. Ma*. Dual-reaction triggered sensitivity amplification for ultrasensitive peptide-cleavage based electrochemical detection of matrix metalloproteinase-7. Biosens. Bioelectron. 2018, 108, 46-52.

17. Z. X. Tang, Y. Y. Fu, Z. F. Ma*. Bovine serum albumin as an effective sensitivity enhancer for peptide-based amperometric biosensor for ultrasensitive detection of prostate specific antigen. Biosens. Bioelectron. 2017, 94, 394-399.

18. Z. X. Tang, L. Y. Wang, Z. F. Ma*. Triple sensitivity amplification for ultrasensitive electrochemical detection of prostate specific antigen. Biosens. Bioelectron. 2017, 92, 577-582.

19. Z. X. Tang, Y. Y. Fu, Z. F. Ma*. Multiple signal amplification strategy for ultrasensitive label-free electrochemical immunoassay for carbohydrate antigen 24-2 based on redox hydrogel. Biosens. Bioelectron. 2017, 91, 299-305.

20. Z. X. Tang, Z. F. Ma*. Multiple functional strategies for amplifying sensitivity of amperometric immunoassay for tumor markers: A review. Biosens. Bioelectron. 2017, 98, 100-112.

21. J. Shan, Z. F. Ma*. A review on amperometric immunoassays for tumor markers based on the use of hybrid materials consisting of conducting polymers and noble metal nanomaterial. Microchim. Acta 2017, 184, 969-979.

22. D. Shu, F. Feng, H. L. Han, Z. F. Ma*. Prominent adsorption performance of amino-functionalized ultra-light graphene aerogel for methyl orange and amaranth. Chem. Eng. J. 2017, 324, 1-9.

23. Q. F. Rong, F. Feng, Z. F. Ma*. Metal ions doped chitosan-poly(acrylic acid) nanospheres: synthesis and their application in simultaneously electrochemical detection of four markers of pancreatic cancer. Biosens. Bioelectron. 2016, 75, 148-154.

24. Z. F. Ma*, N. Liu. Design of immunoprobes for electrochemical multiplexed tumor marker detection. Expert Review of Molecular Diagnostics 2015, 15, 1075-1083. (Invited Review)

25. L. Y. Wang, N. Liu, Z. F. Ma*. Novel gold-decorated polyaniline derivatives as redox-active species for simultaneous detection of three biomarkers of lung cancer. J. Mater. Chem. B 2015, 3, 2867-2872.

26. Z. F. Wang, N. Liu, F. Feng, Z. F. Ma*. Synthesis of cadmium, lead and copper alginate nanobeads as immunosensing probes for the detection of AFP, CEA and PSA. Biosens. Bioelectron. 2015, 70, 98-105.

27. Z. M. Liu, Q. F. Rong, Z. F. Ma*, H. L. Han*. One-step synthesis of redox-active polymer/Au nanocomposites for electrochemical immunoassay of multiplexed tumor markers. Biosens. Bioelectron. 2015, 65, 307-313.

28. Z. F. Wang, X. Chen, Z. F. Ma*. Chitosan coated cupper and cadmium hexacyanocobaltate nanocubics as immunosensing probes for the construction of multiple analytes platform. Biosens. Bioelectron. 2014, 61, 562-568.

29. N. Liu, Z. M. Liu, H. L. Han, Z. F. Ma*. Graphene oxide reduced directly by redox probes for multiplexed detection of tumor markers. J. Mater. Chem. B 2014, 2, 3292 -3298.

30. X. Chen, Z. F. Ma*. Multiplexed electrochemical immunoassay of biomarkers using chitosan nanocomposites. Biosens. Bioelectron. 2014, 55, 343-349.

31. Z. F. Wang, N. Liu, Z. F. Ma*. Platinum porous nanoparticles hybrid with metal ions as probes for simultaneous detection of multiplex cancer biomarkers. Biosens. Bioelectron. 2014, 53, 324-329.

32. X. L. Jia, Z. M. Liu, N. Liu, Z. F. Ma*. A label-free immunosensor based on graphene nanocomposites for simultaneous multiplexed electrochemical determination of tumor markers. Biosens. Bioelectron. 2014, 53, 160-166.

33. X. L. Jia, X. Chen, J. M. Han, J. Ma, Z. F. Ma*. Triple signal amplification using gold nanoparticles, bienzyme and platinum nanoparticles functionalized graphene as enhancers for simultaneous multiple electrochemical immunoassay. Biosens. Bioelectron. 2014, 53, 65-70.

34. N. Liu, Z. F. Ma*. Au-ionic liquid functionalized reduced graphene oxide immunosensing platform for simultaneous electrochemical detection of multiple analytes. Biosens. Bioelectron. 2014, 51, 184-190.

35. P. P. Bian, J. Zhou, Y. Y. Liu, Z. F. Ma*. One-step fabrication of intense red fluorescent gold nanoclusters and their application in cancer cell imaging. Nanoscale 2013, 5, 6161-6166.

36. X. Chen, X. L. Jia, J. Ma, Z. F. Ma*. Electrochemical immunosensor for simultaneous detection of multiplex cancer biomarkers based on graphene nanocomposites. Biosens. Bioelectron. 2013, 50, 356-361.

37. Y. X. Li, J. Ma, Z. F Ma*. Synthesis of gold nanostars with tunable morphology and their electrochemical application for hydrogen peroxide sensing. Electrochim. Acta 2013, 108, 435-440.

38. Q. Gao, J. M. Han, Z. F. Ma*. Polyamidoamine dendrimers-capped carbon dots/Au nanocrystal nanocomposites and its application for electrochemical immunosensor. Biosens. Bioelectron. 2013, 49, 323-328.

39. J. M. Han, J. Ma, Z. F. Ma*. One-step synthesis of poly(thionine)-Au nano-network and nanowires and its application for non-enzyme biosensing of hydrogen peroxide. Electrochem. Commun. 2013, 33, 47-50.

40. N. Liu, X. Chen, Z. F. Ma*. Ionic liquid functionalized graphene/Au nanocomposites and its application for electrochemical immunosensor. Biosens. Bioelectron. 2013, 48, 33-38.

41. J. M. Han, J. Ma, Z. F. Ma*. One-step synthesis of graphene oxide-thionine-Au nanocomposites and its application for electrochemical immunosensing. Biosens. Bioelectron. 2013, 47, 243-247.

42. Z. M. Liu, Z. F. Ma*. Fabrication of an ultrasensitive electrochemical immunosensor for CEA by conducting long-chain polythiols. Biosens. Bioelectron. 2013, 46, 1-7.

43. X. B. Sun, Z. F. Ma*. Highly stable electrochemical immunosensor for carcinoembryonic antigen. Biosens. Bioelectron. 2012, 35, 470-474.

44. R. M. Wang, J. Di, J. Ma, Z. F. Ma*. Highly sensitive detection of cancer cells by electrochemical impedancespectroscopy. Electrochim. Acta 2012, 61, 179-184.

45. B. Liu, Z. F. Ma*, Synthesis of Ag2S-Ag nanoprisms and their use as oligonucleotide probes. Small 2011, 7, 1587-1592.

46. W. T. Shi, Z. F. Ma*, A novel label-free amperometric immunosensor for carcinoembryonic antigen based on redox membrane. Biosens. Bioelectron. 2011, 26, 3068-3071.

47. W. T. Shi, Z. F. Ma*. Amperometric glucose biosensor based on a triangular silver nanoprisms/chitosan composite film as immobilization matrix. Biosens. Bioelectron. 2010, 26, 1098-1103.

48. C. G. Wang, Y. Chen, T. T. Wang, Z. F. Ma*, Z. M. Su. Monodispersed gold nanorods embedded silica particles as novel Raman labels for biosensing. Adv. Funct. Mater. 2008, 18, 355-361.

49. C. G. Wang, Y. Chen, T. T. Wang, Z. F. Ma*, Z. M. Su, Biorecognition-driven self-assembly of gold nanorods: A rapid and sensitive approach toward antibody sensing. Chem. Mater. 2007, 19, 5809-5811.

50. C. G. Wang, Z. F. Ma*, T. T. Wang, Z. M. Su. Synthesis, assembly and biofunctionalization of silica-coated gold nanorods for colorimetric biosensing. Adv. Funct. Mater. 2006, 16, 1673-1678.

51. Z. F. Ma, S.-F. Sui. Naked-eye sensitive detection of Immunoglubulin G by enlargement of Au-nanoparticles immobilized in vitro. Angew. Chem. Int. Ed. 2002, 14, 2176-2179.

52. Z. F. Ma, J. R. Li, M. H. Liu, J. Cao, Z. Y. Zou, J. Tu, L. Jiang. Colorimetric detection of Escherichia coli by polydiacetylene vesicles functionalized with glycolipid. J. Am. Chem. Soc. 1998, 120, 12678-12679.

 

 

【指导的研究生获国家奖学金情况】

 

 

2020 张娜娜 

2019 楚常顺

2018 郑云 张东生

2017年 王辉强

2016年 单姣

2015年 荣勤峰、邢立文

2014年 徐腾、王子凤

2013年 贾新乐、卞平平、刘娜

2012年 孙晓斌(第一届国奖)